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Risk Factors for the Development of Pedal Edema in Patients Using Pramipexole Arch Neurol 64:820-824, Kleiner-Fisman,G. &Fisman,D.N., 2007 See this aricle in Pubmed Article Abstract Pedal edema is a relatively common outcome in patients with PD receiving pramipexole. History of coronary artery disease increases the risk of developing edema.

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